Maria Manuela of Portugal

Antonis Mor
Dutch c.1516/20–c.1576
María of Portugal 1527–1545
oil on panel
Convent of Las Descalzas Reales, Madrid

Lived: 15 October 1527 – 12 August 1545

First wife and cousin of Philip II (her mother, Catherine of Austria, was sister to Charles I and their grandmother was Joanna of Castile).

Maria Manuela died at the age of 17, shortly after giving birth to a sickly baby, the Infante Don Carlos (1545–68).